Event Title

Design and Synthesis of Novel Flavonoid Derivatives as Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease

Major

Chemistry

Faculty Mentor

Chavonda J. Mills

Keywords

Alzheimer's, AChE inhibitors

Abstract

Acetylcholinesterase acts as a catalyst in the hydrolysis of the neurotransmitter acetylcholine. However, cholinergenic neurons in Alzheimer's patients produce less acetylcholine than in normal patients. Acetylcholinesterase (AChE) inhibitors have been identified as a viable option for the treatment of various symptoms associated with cognitive function in patients with Alzheimer's disease. Structure activity relationship studies indicate that drugs containing rings as well as an amino group, such as donepezil, are strong acetylcholinesterase inhibitors. Naturally occurring flavonoids and their derivatives were examined as potential AChE inhibitors with potentially decreased side effects and increased potency. As a result, the design and synthesis of a novel flavonoid derivative which incorporates these crucial structural elements, is presented as a promising lead for the treatment of Alzheimer's disease.

Session Name:

Chemistry I

Start Date

10-4-2015 9:00 AM

End Date

10-4-2015 10:00 AM

Location

HSB 209

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Design and Synthesis of Novel Flavonoid Derivatives as Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease

HSB 209

Acetylcholinesterase acts as a catalyst in the hydrolysis of the neurotransmitter acetylcholine. However, cholinergenic neurons in Alzheimer's patients produce less acetylcholine than in normal patients. Acetylcholinesterase (AChE) inhibitors have been identified as a viable option for the treatment of various symptoms associated with cognitive function in patients with Alzheimer's disease. Structure activity relationship studies indicate that drugs containing rings as well as an amino group, such as donepezil, are strong acetylcholinesterase inhibitors. Naturally occurring flavonoids and their derivatives were examined as potential AChE inhibitors with potentially decreased side effects and increased potency. As a result, the design and synthesis of a novel flavonoid derivative which incorporates these crucial structural elements, is presented as a promising lead for the treatment of Alzheimer's disease.