Using Rational Drug Design Toward the Synthesis of Novel Flavonoid Derivatives as Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease
Abstract
Research has shown that the neurotransmitter acetylcholine (Ach) is less expressed in the brainof Alzheimer's patients when compared to normal patient's levels. It is proposed that thisdecrease stems from the hydrolysis of Ach by the enzyme acetylcholinesterase. As a result,acetylcholinesterase inhibitors have been identified as a viable option for the treatment of varioussymptoms associated with cognitive function in patients with Alzheimer's disease. Flavonoids,natural products that exhibit acetylcholinesterase inhibitory activity, can potentially serve aspromising leads for the treatment of Alzheimer's disease. Through the use of rational drugdesign, this research project will investigate the design and synthesis of novel flavonoidderivatives that incorporate nitrogen-containing fused heterocyclic rings, which were identifiedthrough SAR as crucial structural elements, in pursuance of an effective treatment ofAlzheimer's disease.
Session Name:
Poster Presentation Session #1 - Poster #47
Start Date
10-4-2015 11:30 AM
End Date
10-4-2015 12:15 PM
Location
HSB 3rd Floor Student Commons
Using Rational Drug Design Toward the Synthesis of Novel Flavonoid Derivatives as Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease
HSB 3rd Floor Student Commons
Research has shown that the neurotransmitter acetylcholine (Ach) is less expressed in the brainof Alzheimer's patients when compared to normal patient's levels. It is proposed that thisdecrease stems from the hydrolysis of Ach by the enzyme acetylcholinesterase. As a result,acetylcholinesterase inhibitors have been identified as a viable option for the treatment of varioussymptoms associated with cognitive function in patients with Alzheimer's disease. Flavonoids,natural products that exhibit acetylcholinesterase inhibitory activity, can potentially serve aspromising leads for the treatment of Alzheimer's disease. Through the use of rational drugdesign, this research project will investigate the design and synthesis of novel flavonoidderivatives that incorporate nitrogen-containing fused heterocyclic rings, which were identifiedthrough SAR as crucial structural elements, in pursuance of an effective treatment ofAlzheimer's disease.