Research Publication Title

Flavanoid Derivtives as Acetylcholine Esterace Inhbitors

Major

Chemistry

Faculty Mentor(s)

Julia Metzker

Abstract

Senior Defense Abstract The hydrolysis of Acetylcholine (ACh) by the enzyme Acetylcholine esterase (AChE) plays an important role in Alzheimer's prevention research. Reduced concentrations of ACh in the brain have been shown to contribute to adverse loss and loss of muscle control, uncontrollable movements and other symptoms attributed to Alzheimer's. The connection between ACh levels in the brain and the inhibition of AChE and the metabolic pathways provide a viable research direction for developing drug and therapies to treat and prevent Alzheimer's. Additionally, flavanoid derivatives have shown promise as AChE inhibitors. This study utilizes nitrogen and oxygen containing flavanoid derivatives to inhibit AChE. Recent work indicates that molecular conformation and functional group arrangement impact the binding affinity to inhibitors. With the goal of better understanding how molecular structure affects the function of flavanoids we have implemented acomputational analysis using density functional theory of series of flavanoid derivatives. Here we present the results of this analysis.

Start Date

10-4-2015 12:15 PM

End Date

10-4-2015 1:00 PM

Location

HSB 3rd Floor Student Commons

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Apr 10th, 12:15 PM Apr 10th, 1:00 PM

Flavanoid Derivtives as Acetylcholine Esterace Inhbitors

HSB 3rd Floor Student Commons

Senior Defense Abstract The hydrolysis of Acetylcholine (ACh) by the enzyme Acetylcholine esterase (AChE) plays an important role in Alzheimer's prevention research. Reduced concentrations of ACh in the brain have been shown to contribute to adverse loss and loss of muscle control, uncontrollable movements and other symptoms attributed to Alzheimer's. The connection between ACh levels in the brain and the inhibition of AChE and the metabolic pathways provide a viable research direction for developing drug and therapies to treat and prevent Alzheimer's. Additionally, flavanoid derivatives have shown promise as AChE inhibitors. This study utilizes nitrogen and oxygen containing flavanoid derivatives to inhibit AChE. Recent work indicates that molecular conformation and functional group arrangement impact the binding affinity to inhibitors. With the goal of better understanding how molecular structure affects the function of flavanoids we have implemented acomputational analysis using density functional theory of series of flavanoid derivatives. Here we present the results of this analysis.