Progress Towards Synthesis of A Novel Trifluoromethyl-Substituted Aurone As A Potential Cyclooxygenase-2 Inhibitor
Abstract
Naturally occurring flavonoid compounds have shown great biological potential, in particular a subclass of flavonoids known as the aurone. Previous studies have shown that aurones exhibit anti-cancer activity as well as a variety of other pharmocological activities, including anti-inflammatory and anti-viral properties. More specifically, these studies indicate that aurones show potential in inhibiting cyclooxygenase-2 activity (COX-2), which plays an integral part in inflammation and its associated diseases, such as cancer. Mills, et. al. recently performed molecular docking studies of several novel aurones at the COX-2 active site. As a continuation of this research, a synthetic pathway for one of the most promising aurone derivatives, a novel trifluoromethyl-substituted aurone, has been proposed. The final target molecule will be synthesized using this route and the novel compound will be characterized.
Session Name:
Poster Presentation Session #2 - Poster #16
Start Date
10-4-2015 12:15 PM
End Date
10-4-2015 1:00 PM
Location
HSB 3rd Floor Student Commons
Progress Towards Synthesis of A Novel Trifluoromethyl-Substituted Aurone As A Potential Cyclooxygenase-2 Inhibitor
HSB 3rd Floor Student Commons
Naturally occurring flavonoid compounds have shown great biological potential, in particular a subclass of flavonoids known as the aurone. Previous studies have shown that aurones exhibit anti-cancer activity as well as a variety of other pharmocological activities, including anti-inflammatory and anti-viral properties. More specifically, these studies indicate that aurones show potential in inhibiting cyclooxygenase-2 activity (COX-2), which plays an integral part in inflammation and its associated diseases, such as cancer. Mills, et. al. recently performed molecular docking studies of several novel aurones at the COX-2 active site. As a continuation of this research, a synthetic pathway for one of the most promising aurone derivatives, a novel trifluoromethyl-substituted aurone, has been proposed. The final target molecule will be synthesized using this route and the novel compound will be characterized.