Event Title
Design and Synthesis of Novel Flavonoid Derivatives as Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease
Faculty Mentor
Chavonda Mills
Keywords
Chavonda Mills
Abstract
Acetylcholinesterase acts as a catalyst in the hydrolysis of the neurotransmitter acetylcholine. However, cholinergenic neurons in Alzheimer’s patients produce less acetylcholine than in normal patients. Acetylcholinesterase (AChE) inhibitors have been identified as a viable option for the treatment of various symptoms associated with cognitive function in patients with Alzheimer’s disease. Structure activity relationship studies indicate that drugs containing rings as well as an amino group, such as donepizil, are strong acetylcholinesterase inhibitors. Flavanoid derivatives have also been shown to inhibit AChE.As a result, the design of novel flavonoid derivatives, which incorporate these crucial structural elements, are presented as promising leads for the treatment of Alzheimer’s disease.
Session Name:
Poster Presentation Session #2 - Poster #10
Start Date
4-4-2014 12:15 PM
End Date
4-4-2014 1:00 PM
Location
HSB 3rd Floor Student Commons
Design and Synthesis of Novel Flavonoid Derivatives as Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease
HSB 3rd Floor Student Commons
Acetylcholinesterase acts as a catalyst in the hydrolysis of the neurotransmitter acetylcholine. However, cholinergenic neurons in Alzheimer’s patients produce less acetylcholine than in normal patients. Acetylcholinesterase (AChE) inhibitors have been identified as a viable option for the treatment of various symptoms associated with cognitive function in patients with Alzheimer’s disease. Structure activity relationship studies indicate that drugs containing rings as well as an amino group, such as donepizil, are strong acetylcholinesterase inhibitors. Flavanoid derivatives have also been shown to inhibit AChE.As a result, the design of novel flavonoid derivatives, which incorporate these crucial structural elements, are presented as promising leads for the treatment of Alzheimer’s disease.