Using Multi-Step Synthesis for the Production of Hydrogels with Adhesive Properties
Faculty Mentor(s) Name(s)
Dr. Catrena Lisse Ph.D
Abstract
Hydrogels are composed of networks of hydrophilic polymer chains, which make great in aqueous environments and extremely biocompatible. Today, hydrogels are being used for controlled drug delivery, fluid control, nerve regeneration and tissue engineering.1 This undergraduate research project will demonstrate the experimental design and multi-step synthesis for the production of remote-activated, polyacrylamide hydrogels utilized for wound care. The first step is the synthesis of the DOPA derivative monomer, N-(3,4-Dihydroxyphenethyl) methacrylamide (DMA). This was achieved by reacting the starting material dopamine hydrochloride and methacrylic anhydride with reaction mediators, sodium tetraborate decahydrate and sodium bicarbonate. The second step in the synthesis was a free radical polymerization of acrylamide, N-isopropylacrylamide and, N-(3,4-dihydroxyphenethyl) methacrylamide, with azobis- (isobutyronitrile) as a catalyst under a nitrogen atmosphere to synthesize poly(dopamine-methacrylamide-co-N-isopropylacrylamide-co-acrylamide). Followed by the final step with the gelation of a hydrogel composed of the synthesized polymer in a pH sensitive complex with aqueous iron (III). To allow for remote deterioration of the hydrogel structure through exposure to intense UV radiation, a photoacidproducer was added to the hydrogel. The presentation will highlight the experimental methodology and results of the project.
Start Date
27-3-2024 11:00 AM
End Date
27-3-2024 11:08 AM
Location
Arts and Sciences 2-70
Using Multi-Step Synthesis for the Production of Hydrogels with Adhesive Properties
Arts and Sciences 2-70
Hydrogels are composed of networks of hydrophilic polymer chains, which make great in aqueous environments and extremely biocompatible. Today, hydrogels are being used for controlled drug delivery, fluid control, nerve regeneration and tissue engineering.1 This undergraduate research project will demonstrate the experimental design and multi-step synthesis for the production of remote-activated, polyacrylamide hydrogels utilized for wound care. The first step is the synthesis of the DOPA derivative monomer, N-(3,4-Dihydroxyphenethyl) methacrylamide (DMA). This was achieved by reacting the starting material dopamine hydrochloride and methacrylic anhydride with reaction mediators, sodium tetraborate decahydrate and sodium bicarbonate. The second step in the synthesis was a free radical polymerization of acrylamide, N-isopropylacrylamide and, N-(3,4-dihydroxyphenethyl) methacrylamide, with azobis- (isobutyronitrile) as a catalyst under a nitrogen atmosphere to synthesize poly(dopamine-methacrylamide-co-N-isopropylacrylamide-co-acrylamide). Followed by the final step with the gelation of a hydrogel composed of the synthesized polymer in a pH sensitive complex with aqueous iron (III). To allow for remote deterioration of the hydrogel structure through exposure to intense UV radiation, a photoacidproducer was added to the hydrogel. The presentation will highlight the experimental methodology and results of the project.