Synthesis of Mesalamine Capped Copper Nanoparticles for the Treatment of Inflammatory Bowel Diseases
Faculty Mentor(s) Name(s)
Peter Rosado
Abstract
Metal nanoparticles have become useful in drug delivery. In this project, mesalamine capped nanoparticles are investigated for their possible use in IBD (Inflammatory Bowel Diseases) such as Ulcerative Colitis and Crohn's disease. This experiment used copper specifically, as copper is a low cost, readily available alternative to both gold and silver metals, and contains anti-inflammatory properties. Copper acetate and mesalamine were combined in a chemical reduction synthesis under basic conditions using hydrazine as a reducing agent, affording the copper nanoparticles. The nanoparticles were also tested under different pH’s, revealing that there is need to increase the pH to induce chemical reduction. Alternatives for hydrazine and basic conditions are currently being studied. This work presents spectroscopical evidence of the synthesis of the mesalamine capped copper nanoparticles, and preliminary results detailing the tuning of reaction conditions.
Start Date
27-3-2024 10:00 AM
End Date
27-3-2024 10:50 AM
Location
Magnolia Ballroom
Synthesis of Mesalamine Capped Copper Nanoparticles for the Treatment of Inflammatory Bowel Diseases
Magnolia Ballroom
Metal nanoparticles have become useful in drug delivery. In this project, mesalamine capped nanoparticles are investigated for their possible use in IBD (Inflammatory Bowel Diseases) such as Ulcerative Colitis and Crohn's disease. This experiment used copper specifically, as copper is a low cost, readily available alternative to both gold and silver metals, and contains anti-inflammatory properties. Copper acetate and mesalamine were combined in a chemical reduction synthesis under basic conditions using hydrazine as a reducing agent, affording the copper nanoparticles. The nanoparticles were also tested under different pH’s, revealing that there is need to increase the pH to induce chemical reduction. Alternatives for hydrazine and basic conditions are currently being studied. This work presents spectroscopical evidence of the synthesis of the mesalamine capped copper nanoparticles, and preliminary results detailing the tuning of reaction conditions.