Ubiquitin-Proteasome-Mediated Protein Degradation and Disorders of the Central Nervous System

Authors

• Ashok N. Hegde, Georgia College & State University
• Logan E. Timm, Georgia College & State University
• Connor J. Sivley, Georgia College & State University
• Shrenik Ramiyaramcharankarthic, Georgia College & State University
• Olivia J. Lowrimore, Georgia College & State University
• Brenna J. Hendrix, Georgia College & State University
• Teodora G. Grozdanov, Georgia College & State University
• William J. Anderson, Georgia College & State University

Document Type

Article

Publication Date

2-1-2025

Publication Title

International Journal of Molecular Sciences

Abstract

Ubiquitin–proteasome-mediated proteolysis post-translationally regulates the amounts of many proteins that are critical for the normal physiology of the central nervous system. Research carried out over the last several years has revealed a role for components of the ubiquitin–proteasome pathway (UPP) in many neurodegenerative diseases such as Parkinson’s disease and Huntington’s disease. Studies have also shown a role for the UPP in mental disorders such as schizophrenia and autism. Even though dysregulation of protein degradation by the UPP is a contributory factor to the pathology underlying many nervous system disorders, the association between the components of the UPP and these diseases is far from simple. In this review, we discuss the connections between the UPP and some of the major mental disorders and neurodegenerative diseases.

Volume Number

26

Issue Number

3

DOI

10.3390/ijms26030966

Recommended Citation

Hegde, Ashok N.; Timm, Logan E.; Sivley, Connor J.; Ramiyaramcharankarthic, Shrenik; Lowrimore, Olivia J.; Hendrix, Brenna J.; Grozdanov, Teodora G.; and Anderson, William J., "Ubiquitin-Proteasome-Mediated Protein Degradation and Disorders of the Central Nervous System" (2025). Faculty and Staff Works. 918.
https://kb.gcsu.edu/fac-staff/918