Revisiting the Synthesis of Cis Platin
Faculty Mentor(s) Name(s)
Peter Rosadoflores
Abstract
One of the most common drugs available for cancer treatment is cis-platin. This drug is utilized in chemotherapy treatments, yet it is expensive to make. Our goal for this experiment is to repeat one of the literature procedures that synthesizes cis-platin in aqueous media, and then repeat the synthesis under hydrothermal conditions using the Monowave 50. The Monowave 50 is a synthesis reactor apparatus that can elevate solvents above their normal boiling points, potentially increasing yields and lowering the time of reaction. Several reactions were conducted to synthesize the precursor to cis-platin from potassium tetrachloroplatinate salt (K2[PtCl4], KI, ammonium hydroxide, and silver nitrate. The reactions yielded yellow to brown powders which were characterized via spectroscopic methods such as NMR, and IR. Further, melting points were taken of the solids. These precursors are utilized in the total synthesis of cis-platin. The goal is to develop a “one-pot” reaction that provides better yields of cis-platin. Preliminary results of the use of the cis-platin precursor to prepare cis-platin, and the reactions using Monowave 50 are also presented.
Start Date
27-3-2024 9:00 AM
End Date
27-3-2024 9:50 AM
Location
Magnolia Ballroom
Revisiting the Synthesis of Cis Platin
Magnolia Ballroom
One of the most common drugs available for cancer treatment is cis-platin. This drug is utilized in chemotherapy treatments, yet it is expensive to make. Our goal for this experiment is to repeat one of the literature procedures that synthesizes cis-platin in aqueous media, and then repeat the synthesis under hydrothermal conditions using the Monowave 50. The Monowave 50 is a synthesis reactor apparatus that can elevate solvents above their normal boiling points, potentially increasing yields and lowering the time of reaction. Several reactions were conducted to synthesize the precursor to cis-platin from potassium tetrachloroplatinate salt (K2[PtCl4], KI, ammonium hydroxide, and silver nitrate. The reactions yielded yellow to brown powders which were characterized via spectroscopic methods such as NMR, and IR. Further, melting points were taken of the solids. These precursors are utilized in the total synthesis of cis-platin. The goal is to develop a “one-pot” reaction that provides better yields of cis-platin. Preliminary results of the use of the cis-platin precursor to prepare cis-platin, and the reactions using Monowave 50 are also presented.